講師の部屋

English

Takeshi Kawarabayashi, M.D., Ph.D.
Department of Neurology,
Institute of Brain Science, Hirosaki University Graduate School of Medicine
5 Zaifu, Hirosaki, Aomori 036-8216, Japan
Tel: +81-172-39-5142
Fax: +81-172-39-5143
Email: tkawara@hirosaki-u.ac.jp

CURRICULUM VITAE
EDUCATION and DEGREES:
1983 M.D. Gunma University School of Medicine
1993 Ph.D. Gunma University School of Medicine, Maebashi
PROFESSIONAL TRANING AND EMPLOYMENT:
2007- Lecturer, Department of Neurology, Hirosaki University Graduate School of Medicine
2006-2007 Assistant, Department of Neurology, Hirosaki University Graduate School of Medicine
2005-2006 Assistant, Department of Neurology, Okayama University Graduate School of Medicine
2002-2005 Clinical Fellow, Department of Neurology, Okayama University Graduate School of Medicine
2000-2002 Clinical Fellow, Sawarabi Spring Hospital
1997-2000 Visiting scientist, Alzheimer Research Center, Department of Pharmacology, Mayo Clinic Jacksonville
1983-1997 Resident, Department of Neurology, Gunma University School of Medicine
AWARDS AND HONORS:
2008 Presentation Award, Hirosaki Medical Society
2001 Presentation Award, Japanease Society for Neurology
1997 Japanese longevity science Foundation
1996 Novartis Foundation
MAJOR RESEARCH INTERESTS:
Clinical Neurology, Alzheimer’s disease, non-AD dementia, Neurodegenerative disease Development of Biomarkers of Neurodegenerative disease
Development of Animal model
Development of disease modifying drugs
Pathogenesis of Alzheimer’s disease
MEMBERSHIPS:
Japanease Society for Dementia (Councilor)
The Japan Geriatrics Society (Councilor)
Japanease Society for Neurology
Japanease Society for Internal Medicine
Society for Neuroscience
CURRENT GRANT FUNDING:
Position: Principal Investigator
Number: 24591246
Grantor: Grant-in-Aid for Scientificy Research (C) from JSPS
Period: 2004-2005
Total Amount: ¥3,900,000
PATENTS:
2009 Transformed soybean plant which stores vaccine, and use thereof (PCT/JP200906997)

PUBLICATIONS:
  • Takamura A, Sato Y, Watabe D, Okamoto Y, Nakata T, Kawarabayashi T, Oddo S, Laferla FM, Shoji M, Matsubara E, Sortilin is required for toxic action of Aβ oligomers (AβOs): Extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways. Life Sci. 2012; 91(23-24):1177-1186.
  • Watanabe M, Adachi Y, Jackson M, Yamamoto-Watanabe Y, Wakasaya Y, Shirahama I, Takamura A, Matsubara E, Kawarabayashi T, Shoji M. An unusual case of elderly-onset CADASIL with multiple cerebrovascular risk factors. J Stroke Cerebrovasc Dis. 2012;21(2):143-145.
  • Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, and Matsubara E, Dissociation of Aβ from lipoprotein in cerebrospinal fluid from Alzheimer’s disease accelerates Aβ42 assembly. J Neurosci Res. 2011;89(6):815-821.
  • Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Urisu T, Yamamoto N, Shoji M, Yanagisawa K, Michikawa M, Matsubara E, Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer’s disease model mouse. Mol Neurodegener, 2011;6(1):20.
  • Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, Murakami T, Abe K, Yamada K, Wakabayashi K, Sasaki A, Westaway D, St.George-Hyslop P, Matsubara E, Shoji M, Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. J Neurosci Res. 2011;89(4):576-584.
  • Seino Y, Kawarabayashi T, Wakasaya Y, Takamura A, Nakahata N, Watanabe M, Yamamoto-Watanabe Y, Matsubara E, Westaway D, Davis P, St.George-Hyslop P, Shoji . Aß amyloid accelerates accumulation of phosphorylated tau in neuronal cytoplasm and processes of double transgenic mice.J Neurosci Res. 2010;88(16):3547-3554.
  • Yamamoto-Watanabe Y, Watanabe M, Jackson M, Akimoto H, Sugimoto K, Yasujima M, Wakasaya Y, Matsubara E, Kawarabayashi T, Harigaya Y, Lyndon AR, Shoji M. Quantification of cystatin C in cerebrospinal fluid from various neurological disorders and correlation with G73A polymorphism in CST3 . Brain Res. 2010;1361:140-145.
  • Yamamoto-Watanabe Y, Watanabe M, Hikichi M, Ikeda Y, Jackson M, Wakasaya Y, Matsubara E, Kawarabayashi T, Kannari K, Shoji M. Prevalence of autosomal dominant cerebellar ataxia in Aomori, the northernmost prefecture of Honshu, Japan.Internal Med. 2010; 49(22):2409-2414.
  • Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M. A Japanese ALS6 family with mutation R521C in the FUS/TLS gene: a clinical, pathological and genetic report. J Neurol Sci. 2010; 296(1-2): 59-63.
  • Wakasaya Y, Watanabe M, Tomiyama M, Suzuki C, Jackson M, Fujimuro M, Kimura T, Seino Y, Kawarabayashi T, Yamamoto-Watanabe Y, Matsubara E, Shirahama I, Takamura A, Nakahata N, Shoji M. An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis. Intern Med. 2009;48(15):1311-1313.
  • Ono K, Ikemoto M, Kawarabayashi T, Ikeda M, Nishinakagawa T, Hosokawa M, Shoji M, Takahashi M, Nakashima M. A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human alpha-synuclein A30P+A53T transgenic mice. Parkinsonism Relat Disord. 2009;15(9):649-654.
  • Ikeda M, Kawarabayashi T, Harigaya Y, Sasaki A, Yamada S, Matsubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, Ueda K, Kuribara H, Ikarashi Y, Nakazato Y, Okamoto K, Abe K, Shoji M. Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology. Brain Res 2009;1250:232-241.
  • Wati H, Kawarabayashi T, Matsubara E, Kasai A, Hirasawa T, Kubota T, Harigaya Y, Shoji M, Maeda S, Transthyretin accelerates vascular Aß deposition in a mouse model of Alzheimer’s disease. Brain Pathol. 2009 Jan;19(1):48-57.
  • Watanabe M, Monai N, Jackson M, Yamamoto-Watanabe Y, Ikeda Y, Suzuki C, Tomiyama M, Kawarabayashi T, Kimura T, Seino Y, Wakasaya Y, Miki Y, Matsubara E, Shoji M, A small trinucleotide expansion in the TBP gene gives rise to a sporadic case of SCA17 with abnormal putaminal findings on MRI. Intern Med. 2008;47(24):2179-2182.
  • Suzuki C, Watanabe M, Tomiyama M, Sugimoto K, Nanba E, Jackson M, Kimura T, Seino Y, Wakasaya Y, Kawarabayashi T, Miki Y, Yamamoto-Watanabe Y, Shoji M, A novel mutation in the arylsulfatase A gene associated with adult-onset metachromatic leukodystrophy without clinical evidence of neuropathy. Eur Neurol. 2008;60(6):310-311.
  • Kurata T, Hayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Kawarabayashi T, Takao Y, Ohta T, Harigaya Y, Manabe Y, Kamiya T, Shoji M, Abe K, Differentiation of PA from early PSP with different patterns of symptoms and CBF reduction. Neurol Res. 2008;30(8):860-867.
  • Xu W, Kawarabayashi T, Matsubara E, Deguchi K, Murakami T, Harigaya Y, Ikeda M, Amari M, Kuwano R, Abe K, Shoji M, Plasma antibodies to Aß40 and Aß42 in patients with Alzheimer’s disease and normal controls. Brain Res. 2008;1219:169-179.
  • Arai A, Tomiyama M, Kannari K, Kimura T, Suzuki C, Watanabe M, Kawarabayashi T, Shen H, Shoji M, Reuptake of L-DOPA-derived extracellular DA in the striatum of a rodent model of Parkinson’s disease via norepinephrine transporter. Synapse. 2008;62(8):632-635.
  • Sasaki A, Kawarabayashi T, Murakami T, Matsubara E, Ikeda M, Hagiwara H, Westaway D, St.George-Hyslop P, Shoji M, Nakazato Y, Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L. Brain Res. 2008;1214:159-168.
  • Kawarabayashi T, Shoji M, Plasma biomarkers of Alzheimer’s disease. Curr Opin Psychiatry. 2008;21(3):260-267.
  • Tomiyama M, Arai A, Kimura T, Suzuki C, Watanabe M, Kawarabayashi T, Shoji M, Exacerbation of chronic pancreatitis induced by anticholinesterase medications in myasthenia gravis. Eur J Neurol. 2008;15(5):e40-41.
  • Kurata T,Kawarabayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Ikeda M, Matsubara E, Westaway D, St.George-Hyslop P, Harigaya Y, Kamiya T, Shoji M, Abe K. Enhanced accumulation of phosphorylated a-synuclein in double transgenic mice expressing mutant ßAPP and presenilin-1. J Neurosci Res. 2007;85(10):2246-2252.
  • Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta Y, Deguchi K, Kurata T, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe, K. PINK1, a gene product of PARK6, accumulates in a-synucleinopathy brains. J Neurol Neurosurg Psychiatry. 2007;78(6):653-654.
  • Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL,
    Harigaya Y, Horne P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki, K, Takahashi M, Fujiwara M, Ishiguro K, Bergeron C, Carlson GA, Abe K, Westaway D, St.George-Hyslop P, Shoji M, Cortical neuronal and glial pathology in
    TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation, Am J Pathol. 2006;169(4):1365-1375.
  • Samura E, Shoji M, Kawarabayashi T, Sasaki A, Matsubara E, Murakami T, Wuhua X, Tamura S, Ikeda M, Ishiguro K, Saido TC, Westaway D, St George Hyslop P, Harigaya Y, Abe K, Enhanced accumulation of tau in doubly transgenic mice expressing mutant ßAPP and presenilin-1. Brain Res. 2006;1094(1):192-199.
  • Harigaya Y, Tomidokoro Y, Ikeda M, Sasaki A, Kawarabayashi T, Matsubara E, Kanai M, Saido TC, Younkin SG, Shoji M Type-specific evolution of amyloid plaque and angiopathy in APPsw mice. Neurosci Lett. 2006;395(1):37-41.
  • Ikeda M, Shoji M, Kawarai T, Kawarabayashi T, Matsubara E, Murakami T, Sasaki A, Tomidokoro Y, Ikarashi Y, Kuribara H, Ishiguro K, Hasegawa M, Yen SH, Chishti MA, Harigaya Y, Abe K, Okamoto K, St George-Hyslop P, Westaway D, Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. Am J Pathol. 2005;166(2):521-531.
  • Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K, Yamada T, Kikuchi H, Taniwaki T, Murai H, Ikezoe K, Furuya H, Kawarabayashi T, Shoji M, Checler F, Iwaki T, Makifuchi T, Takeda K, Kira JI, Tabira T, Intracellular Aß42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer’s disease. FASEB J. 2005;19(2):255-257.
  • Kawarabayashi T, Shoji M, Younkin LH, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG, Dimeric amyloid ß protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer’s disease. J Neurosci. 2004;24(15):3801-3809.
  • Murakami T, Shoji M, Imai Y, Inoue H, Kawarabayashi T, Matsubara E, Harigaya Y, Sasaki A, Takahashi R, Abe K, Pael-R is accumulated in Lewy bodies of Parkinson’s disease. Ann Neurol, 2004;55(3):439-442.
  • Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M, Soluble Aß homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging. 2004;25(7):833-841.
  • Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Shoji M, Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging. 2004;25(4):483-490.
  • Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y, Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neuritis. Virchows Arch. 2002;441(4):358-367.
  • Shoji M, Fukushima K, Wakayama M, Shizuka-Ikeda M, Ikeda Y, Kawakami A, Sakazume Y, Ikeda M, Harigaya Y, Matsubara E, Kawarabayashi T, Murakami T, Nagano I, Manabe Y, Abe K, Intellectual faculities in patients with Alzheimer’s disease regress to the level of a 4-5-year old child. Geriatrics and Gerontology International. 2002;2:143-147.
  • Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH, Reversible memory loss in a mouse transgenic model of Alzheimer’s disease. J Neurosci. 2002;22(15):6331-6335.
  • Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castaño EM, St. George-Hyslop P, Shoji M, Generation of amyloid ß protein from a presenilin-1 and ßAPP complex. Biocem Biophys Res Commun. 2002;292(2):571-578.
  • Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe W, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ich K, Yoshida H, Toji H, Nakamura S, Hirai H, Cerebrospinal fluid tau in dementia disorders: A large scale multicenter study by a Japanese study group. Neurobiol Aging. 2002;23(3):363-370.
  • Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH, The relationship between Aß and memory in the Tg2576 mouse model of Alzheimer’s disease. J Neurosci. 2002;22(5):1858-1867.
  • Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE, Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis. 2002;9(1):11-23.
  • Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG, Age-dependent changes in brain, CSF, and plasma amyloid ß protein in the Tg2576 transgenic mouse model of Alzheimer’s disease. J Neurosci. 2001;21(2):372-381.
  • Yu H, Saura CA, Choi S, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel ER, Kirkwood A, Shen J, APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 2001;31(5):713-726.
  • Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin SG, Shoji M, Brain Aß amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. J Pathol. 2001;194(4):500-506.
  • Tomidokoro Y, Ishiguro K, Harigaya Y, Matsubara E, Ikeda M, Park JM, Yasutake K, Kawarabayashi T, Okamoto K, Shoji M, Aß amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice. Neurosci Lett. 2001;299(3):169-172.
  • Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Okamoto K, Shoji M, Impaired neurotransmitter systems by Aß amyloidosis in APPsw transgenic mice overexpressing amyloid ß protein precursor. Neurosci Lett. 2000;292(3):155-158.
  • Tucker HM, Kihiko M, Caldwell JN, Wright S, Kawarabayashi T, Price D, Walker D, Scheff S, McGillis JP, Rydel RE, Estus S, The plasmin system is induced by and degrades amyloid-ß aggregates. J Neurosci. 2000;20(11):3937-3946.
  • Shoji M, Kawarabayashi T, Matsubara E, Ikeda M, Ishiguro K, Harigaya Y, Okamoto K, Distribution of amyloid ß protein precursor in the Alzheimer’s disease brain. Psychiatry Clin Neurosci. 2000;54(1):45-54.
  • Shoji M, Kawarabayashi T, Sato M, Sasaki A, Saido TC, Matsubara E, Tomidokoro Y, Kanai M, Shizuka M, Ishiguro K, Ikeda M, Harigaya Y, Okamoto K, Hirai S, Age-related amyloid ß protein accumulation induces cellular death and macrophage activation in transgenic mice. J Pathol. 2000;191(1):93-101.
  • Tomidokoro Y, Ishiguro K, Igeta Y, Matsubara E, Kanai M, Shizuka M, Kawarabayashi T, Harigaya Y, Kawakatsu S, Ii K, Ikeda M, St George-Hyslop PH, Hirai S, Okamoto K, Shoji M, Carboxyl-terminal fragments of presenilin-1 are closely related to cytoskeletal abnormalities in Alzheimer’s brains. Biochem Biophys Res Commun. 1999;256(3):512-518.
  • Shoji M, Matsubara E, Kanai M, Watanabe M, Nakamura T, Tomidokoro Y, Shizuka M, Wakabayashi K, Igeta Y, Ikeda Y, Mizushima K, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Hirai S, Combination assay of CSF tau, Aß1-40 and Aß1-42(43) as a biochemical marker of Alzheimer’s disease. J Neurol Sci. 1998;158(2):134-140.
  • Kanai M, Matsubara E, Isoe K, Urakami K, Nakashima K, Arai H, Sasaki H, Abe K, Iwatsubo T, Kosaka T, Watanabe M, Tomidokoro Y, Shizuka M, Mizushima K, Nakamura T, Igeta Y, Ikeda Y, Amari M, Kawarabayashi T, Ishiguro K, Harigaya Y, Wakabayashi K, Okamoto K, Hirai S, Shoji M, Longitudinal study of cerebrospinal fluid levels of tau, Aß1-40, and Aß1-42(43) in Alzheimer’s disease: a study in Japan. Ann Neurol. 1998;44(1):17-26.
  • Shoji M, Kawarabayashi T, Sato M, Sasaki A, Matsubara E, Igeta Y, Kanai M, Tomidokoro Y, Shizuka M, Ishiguro K, Harigaya Y, Okamoto K, Hirai S, Accumulation of amyloid ß protein in transgenic mice. Neurobiol Aging. 1998;19(1 Suppl):S59-63.
  • Igeta Y, Kawarabayashi T, Sato M, Yamada N, Matsubara E, Ishiguro K, Kanai M, Tomidokoro Y, Osuga J, Okamoto K, Hirai S, Shoji M, Apolipoprotein E accumulates with the progression of Aß deposition in transgenic mice. J Neuropathol
    Exp Neurol. 1997;56(11):1228-1235.
  • Kawarabayashi T, Igeta Y, Sato M, Sasaki A, Matsubara E, Kanai M, Tomidokoro Y, Ishiguro K, Okamoto K, Hirai S, Shoji M, Lysosomal generation of amyloid ß protein species in transgenic mice. Brain Res. 1997;765(2):343-348.
  • Sato M, Kawarabayashi T, Shoji M, Kobayashi T, Tada N, Matsubara E, Hirai S, Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-ß protein precursor. Dement
    Geriatr Cogn Disord. 1997;8(5):296-307.
  • Kawarabayashi T, Shoji M, Sato M, Sasaki A, Ho L, Eckman CB, Prada CM, Younkin SG, Kobayashi T, Tada N, Matsubara E, Iizuka T, Harigaya Y, Kasai K, Hirai S, Accumulation of ß-amyloid fibrils in pancreas of transgenic mice. Neurobiol Aging. 1996;17(2):215-222.
  • Iizuka T, Shoji M, Kawarabayashi T, Sato M, Kobayashi T, Tada N, Kasai K, Matsubara E, Watanabe M, Tomidokoro Y, Hirai S, Intracellular generation of amyloid ß-protein from amyloid beta- and gamma-secretase. Biochem Biophys Res Commun. 1996;218(1):238-242.
  • Shoji M, Kawarabayashi T, Sato M, Sasaki A, Matsubara E, Iizuka T, Harigaya Y, Hirai S, Systemic overexpression of a C-terminal fragment of human amyloid ß-protein precursor causes accumulation of Alzheimer ß-amyloid fibrils in pancreas of transgenic mice. Gerontology. 1996;42 (Suppl 1):48-56.
  • Iizuka T, Shoji M, Harigaya Y, Kawarabayashi T, Watanabe M, Kanai M, Hirai S, Amyloid ß-protein ending at Thr43 is a minor component of some diffuse plaques in the Alzheimer’s disease brain, but is not found in cerebrovascular amyloid. Brain Res. 1995;702(1-2):275-278.
  • Harigaya Y, Shoji M, Kawarabayashi T, Kanai M, Nakamura T, Iizuka T, Igeta Y, Saido TC, Sahara N, Mori H, Hirai S, Modified amyloid ß protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer’s disease. Biochem Biophys Res Commun. 1995;211(3):1015-1022.
  • Yamaguchi H, Yamazaki T, Kawarabayashi T, Sun X, Sakai Y, Hirai S, Localization of Alzheimer amyloid ß protein precursor and its relation to senile plaque amyloid. Gerontology. 1994;40(Suppl 2):65-70.
  • Yamaguchi H, Ishiguro K, Sugihara S, Nakazato Y, Kawarabayashi T, Sun X, Hirai S, Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer ß-amyloid deposition. Acta
    Neuropathol. 1994;88(5):413-419.
  • Yamazaki T, Yamaguchi H, Kawarabayashi T, Hirai S, Ultrastructural localization of amyloid ß/A4 protein precursor in the normal rat brain. Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;63(3)173-180.
  • Kawarabayashi T, Shoji M, Yamaguchi H, Tanaka M, Harigaya Y, Ishiguro K, Hirai S, Amyloid ß protein precursor accumulates in swollen neurites throughout rat brain with aging. Neurosci Lett. 1993;153(1):73-76.
  • Ikeda M, Shoji M, Yamaguchi H, Matsubara E, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Hirai S, Diagnostic significance of skin immunolabelling with antibody against native cerebral amyloid in Alzheimer’s disease. Neurosci Lett.
    1993;150(2):159-161.
  • Ishiguro K, Shoji M, Yamaguchi H, Matsubara E, Ikeda M, Kawarabayashi T, Harigaya Y, Okamoto K, Hirai S, Differential expression of alpha 1-antichymotrypsin in the aged human brain. Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;64(4):221-227.
  • Yamazaki T, Yamaguchi H, Nakazato Y, Ishiguro K, Kawarabayashi T, Hirai S, Ultrastructural characterization of cerebellar diffuse plaques in Alzheimer’s disease. J Neuropathol Exp Neurol. 1992;51(3):281-286.
  • Kawarabayashi T, Shoji M, Harigaya Y, Yamaguchi H, Hirai S, Expression of APP in the early stage of brain damage. Brain Res. 1991;563(1-2):334-338.
  • Kawarabayashi T, Shoji M, Harigaya Y, Yamaguchi H, Hirai S, Amyloid ß/A4 protein precursor is widely distributed in both the central and peripheral nervous systems of the mouse. Brain Res. 1991;552(1):1-7.
  • Yamaguchi H, Nakazato Y, Kawarabayashi T, Ishiguro K, Ihara Y, Morimatsu M, Hirai S, Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia. Acta Neuropathol.1991;81(6):603-609.
  • Okamoto K, Hirai S, Ishiguro K, Kawarabayashi T, Takatama M, Light and electron microscopic and immunohistochemical observations of the Onuf’s nucleus of amyotrophic lateral sclerosis. Acta Neuropathol. 1991;81(6):610-614.
  • Yamaguchi H, Nakazato Y, Yamazaki T, Shoji M, Kawarabayashi T, Hirai S, Subpial ß/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia. Neurosci Lett. 1991;123(2):217-220.
  • Shoji M, Kawarabayashi T, Harigaya Y, Yamaguchi H, Hirai S, Kamimura T, Sugiyama T, Alzheimer amyloid ß-protein precursor in sperm development. Am J Pathol. 1990;137(5):1027-1032.
  • Shoji M, Hirai S, Harigaya Y, Kawarabayashi T, Yamaguchi H, The amyloid ß-protein precursor is localized in smooth muscle cells of leptomeningeal vessels. Brain Res. 1990;530(1):113-116.
  • Shoji M, Hirai S, Yamaguchi H, Harigaya Y, Kawarabayashi T, Amyloid ß-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia. Brain Res. 1990;512(1):164-168.
  • Tanaka M, Suzuki H, Kawarabayashi T, Morimatsu M, Hirai S, Palatal myoclonus disappears in sleep. Neurology. 1984;34(3):406-407.