教授の部屋

ENGLISH

Mikio Shoji, MD., PhD.
Professor, Department of Neurology
Institute of Brain Science, Hirosaki University Graduate School of Medicine
5-Zaifu-Cho, Hirosaki, Aomori 036-8216, Japan
TEL: +80-172-39-5142; FAX: +81-172-39-5143
e-mail: mshoji@hirosaki-u.ac.jp; http://www.h-shinnai.jp

Curriculum Vitae
Education and Degree:
1980 M.D. Gunma University School of Medicine
1989 PhD. Gunma University School of Medicine, Department of Neurology
Professional Background:
2006~ Professor, Department of Neurology,
Hirosaki University Graduate School of Medicine
2001-2005 Associate Professor, Department of Neurology,
Okayama University Graduate School of Medicine
1991-1992 Research fellows, Case Western Resaerve4 University,
Steve Younkin Lab.
1990~ Lecturer, in Department of Neurology, Gunma University Hospital
1985~ Assistant in Department of Neurology, Gunma University Hospital
~1984 Clinical fellow, Geriatrics Research Institute Hospital
~1983 Resident, Gunma University Hospital
Major Research Interests:
Clinical Neurology, Alzheimer’s disease, non-AD dementia,
Neurodegenerative disease, Stroke, Biomarkers, Animal models,
Development of disease modifying drugs
Consortium studies:
Japanese Genetic Study Consortium for Alzheimer’s Disease
Japanese Alzheimer Disease Neuroimaging Initiative
Awards and Honors:
1989 Sasakawa Health Science Foundation
1991 The Univers foundation for Research
1993 Sandz Foundation for Gerontological Research
1996 Mochida Memorial Foundation for Medical and Pharmaceutical Research
Life Science Foundation of Japan
2006 Hirosaki University Hospital Grant-in-Aid for Medical encouragement
2007 Takeda Medical Research Foundation
The Karoji Memorial Fund for Medical Research
2010 AstraZeneca Research & Development Grant
Patents:
2009 Transformed soybean plant which stores vaccine, and use thereof
(PCT/JP200906997)
2000 Transgenic mouse ß-amyloid transgene; US patent No: 6,037,521
1994 Transgenic animal for Alzheimer’s disease;
European Patent No: 94117512.7
Memberships:
Societas Neurologica Japonica, The Japanese Society of Internal Medicine,
The Japan Geriatrics Society, The Japan Stroke Society,
Japanese Society of Dementia Research, Society of Neuroscience,
American Academy of Neurology
Current Grant Funding:
Grant-in-Aid for challenging Exploratory Research from Japan Society for the Promotion of Science
Grant from the Ministry of Health, Labor, and Welfare of Japan (The Amyloidosis Research Committee Research on Intractable Diseases, Clinical Research Network for Dementia)

Major Publications:
  • Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama S, Hashimoto Y, Miyajima M, Arai H, Nagashima Y, Yamaguchi H, Kuwano R, Nagaike K, Ihara Y; the Japanese Alzheimer’s Disease Neuroimaging Initiative. Altered γ-secretase activity in mild cognitive impairment and Alzheimer’s disease. EMBO Mol Med. 2012 Apr; 4(4):344-52. (3 Citations)
  • Abe K, Ikeda Y, Kurata T, Ohta Y, Manabe Y, Okamoto M, Takamatsu K, Ohta T, Takao Y, Shiro Y, Shoji M, Kamiya T, Kobayashi H, Koizumi A. Cognitive and affective impairments of a novel SCA/MND crossroad mutation Asidan. Eur J Neurol. 2012 Aug; 19(8):1070-8
  • Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Urisu T, Yamamoto N, Shoji M, Yanagisawa K, Michikawa M, Matsubara E. Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer’s disease model mouse. Mol Neurodegener. 2011 Mar 6; 6(1):20. (10 Citaions)
  • Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, Murakami T, Abe K, Yamada K, Wakabayashi K, Sasaki A, Westaway D, Hyslop PS, Matsubara E, Shoji M. Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. J Neurosci Res. 2011 Apr; 89(4):576-84 (5 Citaion)
  • Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M. A Japanese ALS6 family with mutation R521C in the FUS/TLS gene: a clinical, pathological and genetic report. J Neurol Sci. 2010 Sep 15; 296(1-2):59-63. (10 Citations)
  • Seino Y, Kawarabayashi T, Wakasaya Y, Watanabe M, Takamura A, Yamamoto-Watanabe Y, Kurata T, Abe K, Ikeda M, Westaway D, Murakami T, Hyslop PS, Matsubara E, Shoji M. Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double-transgenic mouse model. J Neurosci Res. 2010 Dec; 88(16):3547-54. (2 Citaion)
  • Ikeda M, Kawarabayashi T, Harigaya Y, Sasaki A, Yamada S, Matsubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, Ueda K, Kuribara H, Ikarashi Y, Nakazato Y, Okamoto K, Abe K, Shoji M. Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology. Brain Res. 2009 Jan 23; 1250:232-41. (10 Citations)
  • Xu W, Kawarabayashi T, Matsubara E, Deguchi K, Murakami T, Harigaya Y, Ikeda M, Amari M, Kuwano R, Abe K, Shoji M. Plasma antibodies to Abeta40 and Abeta42 in patients with Alzheimer’s disease and normal controls. Brain Res. 2008 Jul 11; 1219:169-79. (14 Citaions)
  • Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R; Japanese Genetic Study Consortium for Alzeheimer’s Disease. Genetic association of CTNNA3 with late-onset Alzheimer’s disease in females. Hum Mol Genet. 2007 Dec 1; 16(23):2854-69. (18 Citations)
  • Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL, Harigaya Y, Horne P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki K, Takahashi M, Fujiwara M, Ishiguro K, Bergeron C, Carlson GA, Abe K, Westaway D, St George-Hyslop P, Shoji M. Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. Am J Pathol. 2006 Oct; 169(4):1365-75. (35 citations)
  • Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Tsukie T, Toyabe S, Akazawa K, Kanazawa I, Ihara Y; Japanese Genetic Study Consortium for Alzheimer’s Disease. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer’s disease. Hum Mol Genet. 2006 Jul 1; 15(13):2170-82. (39 citations)
  • Harigaya Y, Tomidokoro Y, Ikeda M, Sasaki A, Kawarabayashi T, Matsubara E, Kanai M, Saido TC, Younkin SG, Shoji M. Type-specific evolution of amyloid plaque and angiopathy in APPsw mice. Neurosci Lett. 2006 Feb 27; 395(1):37-41. (13 Citation)
  • Ikeda M, Shoji M, Kawarai T, Kawarabayashi T, Matsubara E, Murakami T, Sasaki A, Tomidokoro Y, Ikarashi Y, Kuribara H, Ishiguro K, Hasegawa M, Yen SH, Davies P, Chishti M A, Harigaya Y, Okamoto K, Abe K, Carlson GA, St.George-Hyslop P, Westaway D. Accumulation of Filamentous Tau in the Cerebral Cortex of Human Tau R406W Transgenic Mice. Am J Pathol 2005; 166(2): 521-31. (60 Citations)
  • Asami-Odaka A, Obayashi-Adachi Y, Matsumoto Y, Takahashi H, Fukumoto H, Horiguchi T, Suzuki N, and Shoji M . Passive Immunization of the Aß42(43) C-Terminal-Specific Antibody BC05 in a Mouse Model of Alzheimer’s Disease. Neurodegenerative Disease 2005; 2: 36 – 43. (35 Citations)
  • Moreira MC, Klur S, Watanabe M, Nemeth AH, Ber IL, Moniz JC, Tranchant C, Aubourg P, Tazir M, Schols L, Pandolfo M, Schulz JB, Pouget J, Calvas P, Shizuka-Ikeda M, Shoji M, Tanaka M, Izatt L, Shaw CE, M’Zahem A, Dunne E, Bomont P, Benhassine T, Bouslam N, Stevanin G, Brice A, Guimaraes J, Mendonca P, Barbot C, Coutinho P, Sequeiros J, Durr A, Warter JM, Koenig M. Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2. Nature Genetics 2004; 69: 225-7. (185 citations)
  • Ikeda Y, Dalton JC, Moseley ML, Gardner KL, Bird TD, Ashizawa T, Seltzer WK, Pandolfo M, Milunsky A, Potter NT, Shoji M, Vincent JB, Day JW, Ranum LP. Spinocerebellar Ataxia Type 8: Molecular Genetic Comparisons and Haplotype Analysis of 37 Families with Ataxia. Am J Hum Genet 2004; 75(1): 3-16. (43 citations)
  • Kawarabayashi T, Shoji M, Younkin L, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH and Younkin SG. Dimeric Aß Rapidly Accumulates in Lipid Rafts Followed by ApoE and Phosphorylated Tau as Memory is Impaired in the Tg2576 Mouse Model of Alzheimer’s Disease. J Neurosci 2004; 24(15): 3801-9. (198 Citations)
  • Murakami T, Shoji-M, Imai Y, Inoue H, Kawarabayashi T, Matsubara E, Harigaya Y, Sasaki A, Takahashi R and Abe K. Pael-R is accumulated in Lewy bodies of Parkinson’s disease. Annals of Neurology 2004, 55: 439-442. (77 Citations)
  • Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Shoji M. Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiology of Aging 2004; 25: 483-90. (25 Citations)
  • Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M. Soluble Aß homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiology of Aging 2004; 25(7):833-41. (15 Citations)
  • Iwai M, Sato K, Kamada H, Omori N, Nagano I, Shoji M, Abe K. Temporal profile of stem cell division, migration, and differentiation from subventricular zone to olfactory bulb after transient forebrain ischemia in gerbils. Journal of Cerebral Blood Flow and Metabolism. 2003 Mar; 23(3):331-41. (96 Citations)
  • Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. Journal of Biological Chemistry 2003, 278: 51901-51910. (52 Citations)
  • Matsubara E, Bryant-Thomas T, Pacheco J, Henry TL, Poeggeler B, Manjon M, Herbert D, Cruz-Sanchez F, Chyan Y-J, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson G, Ghiso J, Williams C, Refolo LM, Pappolla MA. Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer’s disease. Journal of Neurochemistry 2003; 85: 1101~8. (168 Citations)
  • Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe W, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ich K, Yoshida H, Toji, H Nakamura S, Hirai H. Cerebrospinal fluid tau in dementia disorders: A large scale multicenter study by a Japanese study group. Neurobiol Aging 2002; 23:363~70. (47 citations)
  • Iwai M, Sato K, Omori N, Nagano I, Manabe Y, Shoji M, Abe K. Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia. Journal of Cerebral Blood Flow and Metabolism 2002; 22: 411~9. (122 citations)
  • Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiology of Disease 2002; 9: 11~23. (297 Citations)
  • Shoji M, Kanai M, Matsubara E, Tomidokoro Y, Shizuka M, Ikeda Y, Ikeda M, Harigaya Y, Okamoto K, Hirai S. The levels of cerebrospinal fluid Aß40 and Aß42(43) are regulated age-dependently. Neurobiology of Aging 2001; 22: 209~15. (44 Citations)
  • Tomidokoro Y, Ishiguro K, Harigaya Y, Matsubara E, Ikeda M, Park JM, Yasutake K, Kawarabayashi T, Okamoto K, Shoji M. Aß amyloidosis induces the initial stage of tau accumulation in APP (sw) mice. Neuroscience Letters 2001; 299: 169~72. (83 Citations)
  • Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer’s disease. J Neurosci 2001; 21: 372~81. (656 Citations)
  • Shoji M, Kanai M, Matsubara E, Ikeda M, Harigaya Y, Okamoto K, Hirai S. Taps to Alzheimer’s patients: a continuous Japanese study of cerebrospinal fluid biomarkers. Annals of Neurology 2000; 48: 402. (20 Citations)
  • Shoji M, Harigaya Y, Sasaki A, Ueda K, Ishiguro K, Matsubara E, Watanabe M, Ikeda M, Kanai M, Tomidokoro Y, Shizuka M, Amari M, Kosaka K, Nakazato Y, Okamoto K, Hirai S. Accumulation of NACP/alpha-synuclein in Lewy body disease and multiple system atrophy. Journal of Neurology Neurosurgery and Psychiatry 2000, 68: 605~608. (32 Citations)
  • Harigaya Y, Saido TC, Eckman CB, Prada CM, Shoji M, Younkin SG. Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer’s disease brain. Biochemial and Biophysical Research Communications 2000; 276: 422~7. (90 Citations)
  • Ikeda Y, Shizuka M, Watanabe M, Okamoto K, Shoji M. Molecular and clinical analyses of spinocerebellar ataxia type 8 in Japan. Neurology 2000; 54: 950~5. (63 Citations)
  • Kanai M, Shizuka M, Urakami K, Matsubara E, Harigaya Y, Okamoto K, Shoji M. Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer’s disease. Neuroscience Letters 1999; 267: 65~8. (49 Citations)
  • Matsubara E, Ghiso J, Frangione B, Amari M, Tomidokoro Y, Ikeda Y, Harigaya Y, Okamoto K, Shoji M. Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer’s disease and Down’s syndrome. Annals of Neurology 1999; 45: 537~41 (73 Citations)
  • Shoji M, Matsubara E, Kanai M, Watanabe M, Nakamura T, Tomidokoro Y, Shizuka M, Wakabayashi K, Igeta Y, Ikeda Y, Mizushima K, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Hirai S. Combination assay of CSF tau, A ß 1-40 and A ß 1-42(43) as a biochemical marker of Alzheimer’s disease. Journal of the Neurological Sciences 1998; 158: 134~40. (163 Citations)
  • Shoji M, Kawarabayashi T, Sato M, Sasaki A, Matsubara E, Igeta Y, Kanai M, Tomidokoro Y, Shizuka M, Ishiguro K, Harigaya Y, Okamoto K, Hirai S. Accumulation of amyloid ß protein in transgenic mice. Neurobiology of Aging 1998; 19: S59~63. (5 Citation)
  • Watanabe M, Sugai Y, Concannon P, Koenig M, Schmitt M, Sato M, Shizuka M, Mizushima K, Ikeda Y, Tomidokoro Y, Okamoto K, Shoji M. Familial spinocerebellar ataxia with cerebellar atrophy, peripheral neuropathy, and the elevated level of serum creatine kinase, γ-globulin and α-fetoprotein. Annals of Neurology 1998; 44: 265~9. (32 Citations)
  • Kanai M, Matsubara E, Isoe K, Urakami K, Nakashima K, Arai H, Sasaki H, Abe K, Iwatsubo T, Kosaka T, Watanabe M, Tomidokoro Y, Shizuka M, Mizushima K, Nakamura T, Igeta Y, Ikeda Y, Amari M, Kawarabayshi T, Ishiguro K, Harigaya Y, Wakabayashi K, Okamoto K, Hirai S, Shoji M. Longitudinal study of cerebrospinal fluid levels of tau, Aß1-40 and Aß1-42(43) in Alzheimer’s disease: A study in Japan. Ann Neurol 1998; 44: 17~26. (347 Citation)
  • Aoki M, Abe K, Oda N, Ikeda M, Tsuda T, Kanai M, Shoji M, St.George-Hyslop PH, Itoyama Y. A presenilin-1 mutation in a Japanese family with Alzheimer’s disease and distinctive abnormalities on cranial MRI. Neurology 1997; 48: 1118~20. (14 Citations)
  • Ikeda M, Sharma V, Sumi SM, Rogaeva E, Poorkaj P, Sherrington R, Nee L, Tsuda T, Oda, N, Watanabe M, Aoki M, Shoji M, Abe K, Itoyama Y, Hirai S, Schellenberg GD, Bird TD and St George-Hyslop PH. The clinical phenotype of two missense mutations in the presenilin I gene in Japanese patients. Annals of Neurology 1996; 40: 912~7. (38 Citations)
  • Castano EM, Prelli F, Soto C, Beavis R, Matsubara E, Shoji M, Frangione B. The length of amyloid-ß in hereditary cerebral haemorrhage with amyloidosis, Dutch type: Implication for the role of amyloid-ß 1-42 in Alzheimer’s disease. Journal of Biological Chemistry 1996; 271: 32185~91. (74 Citations)
  • Kawarabayashi T, Shoji M, Sato M, Sasaki A, Ho L, Eckman EB, Prada C, Younkin SG, Kobayashi T, Tada N, Matsubara E, Iizuka T, Harigaya Y, Kasai K, Hirai S. Accumulation of ß amyloid fibrils in pancreas of transgenic mice. Neurobiology of Aging 1996; 17: 215~22. (61 Citations)
  • Harigaya Y, Shoji M, Shirao T, Hirai S. Disapprearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer’s disease. Journal of Neuroscience Research 1996; 43: 87~92. (99 Citaion)
  • Harigaya Y, Shoji M, Kawarabayashi T, Kanai M, Nakamura T, Iizuka T, Igeta Y, Saido TC, Sahara N, Mori H, Hirai S. Modified amyloid ß protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer’s disease. Biochemial and Biophysical Research Communications 1995; 211: 1015~22. (44 Citation)
  • Iizuka T, Shoji M, Harigaya Y, Kawarabayashi T, Watanabe M, Kanai M, Hirai S. Amyloid ß -protein ending at Thr 43 is a minor component of diffuse plaques in the Alzheimer’s disease brain, but is not found in cerebrovascular amyloid. Brain Research 1995; 702: 275~8. (11 Citations)
  • Mori H, Hosoda K, Matsubara E, Nakamoto T, Furiya Y, Endoh R, Usami M, Shoji M, Maruyama S, Hirai S. Tau in the cerebrospinal fluids: establishment of the sandwitch ELISA with antibody specific to the repeat sequence in tau. Neuroscience Letters 1995; 186: 181~3. (109 Citations)
  • Ikeda M, Abe K, Aoki M, Ogasawara M, Kameya T, Watanabe M, Shoji M, Hirai S, Itoyama Y. A novel point mutation in the Cu/Zn superoxide dismutase gene in a patients with familial amyotrophic lateral screlosis. Human Molecular Genetics 1995; 4: 491~2. (24 Citations)
  • Ikeda M, Abe K, Aoki M, Sahara M, Watanabe M, Shoji M, Hirai S, Itoyama Y. Variable clinical symptoms in familial amyotrophic lateral sclerosis with a novel point mutation in the Cu/Zn superoxide dismutase gene. Neurology 1995; 45: 2038~42. (36 Citations)
  • Nakamura T, Shoji M, Harigaya Y, Watanabe M, Hosoda K, Cheung TT, Shaffer LM, Golde TE, Younkin LH, Younkin SG, Hirai S. Amyloid ß protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer’s disease. Annals of Neurology 1994; 36: 903~11. (100 Citations)
  • Kawarabayashi T, Shoji M, Yamaguchi H, Tanaka M, Harigaya Y, Ishiguro K, Hirai S. Amyloid ß protein precursor accumulates in swollen neurites throughout rat brain with aging. Neuroscience Letters 1993; 153: 73~6. (32 Citations)
  • Shoji M, Golde TE, Ghiso J, Cheung TT, Estus S, Shaffer LM, Cai X-D, McKay DM, Titner R, Frangione B, Younkin SG. Production of the Alzheimer Amyloid ß protein by normal proteolytic processing. Science 1992; 258: 126~9. (1246 citations)
  • Shoji M, Hirai S, Yamaguchi H, Harigaya Y, Ishiguro K, Matsubara E. α1-antichymotrypsin is present in diffuse senile plaques; A comparative study of ß-protein and α1-antichymotrypsin immunostaining in the Alzheimer brain. American Journal of Pathology 1991; 138: 247~57. (53 Citation)
  • Kawarabayashi T, Shoji M, Harigaya Y, Yamaguchi H, Hirai S. Expression of APP in the early stage of brain damage. Brain Research 1991; 563: 334~8. (143 citations)
  • Shoji M, Kawarabayashi T, Harigaya Y, Yamaguchi H, Hirai S, Kamimura T, Sugiyama T. Alzheimer amyloid ß-protein precursor in sperm development. American Journal of Pathology 1990; 137: 1027~32. (14 Citation)
  • Shoji M, Hirai S, Harigaya Y, Kawarabayashi T, Yamaguchi H. The amyloid ß-protein precursor is localized in smooth muscle cells of leptomeningeal vessels. Brain Research 1990; 530: 113~6. (52 citation)
  • Shoji M, Hirai S, Yamaguchi H, Harigaya Y, Kawarabayashi T. Amyloid ß-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia. Brain Research 1990; 512: 164~8. (91 Citaion)
  • Matsubara E, Hirai S, Amari M, Shoji M, Yamaguchi H, Okamoto K, Ishiguro K, Harigaya, Y Wakabayashi K. α1-antichymotrypsin as a possible biological marker for Alzheimer-type dementia. Annals of Neurology 1990; 28: 561~7. (144 Citations)
  • Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Harigaya Y. Diffuse type of senile plaques in the brains of Alzheimer-type dementia. Acta Neuropathologica 1988; 77: 113~9. (197 Citation)
  • Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Ihara Y. A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by ß protein immunostaining. Acta Neuropathologica 1988; 76: 541~9. (247 Citation)